Description
5'-Phosphoguanylyl-(3',5')-guanosine (pGpG) is an intermediate molecule produced by the pathway for enzymatic cyclic diguanylate (c-di-GMP) degradation. 5'-Phosphoguanylyl-(3',5')-guanosine can be used to detect the metabolism of nucleic acids.
Product information
CAS Number: 33008-99-0
Molecular Weight: 708.43
Formula: C20H26N10O15P2
Chemical Name: {[(2R, 3S, 4R, 5R)-5-(2-amino-6-oxo-6, 9-dihydro-3H-purin-9-yl)-3-[({[(2R, 3S, 4R, 5R)-5-(2-amino-6-oxo-6, 9-dihydro-3H-purin-9-yl)-3, 4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]-4-hydroxyoxolan-2-yl]methoxy}phosphonic acid
Smiles: NC1NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)O[C@@H]3[C@@H](COP(O)(O)=O)O[C@H]([C@@H]3O)N3C=NC4=C3NC(N)=NC4=O)[C@@H](O)[C@H]2O)C(=O)N=1
InChiKey: ZEHOHLFQOXAZHX-MHARETSRSA-N
InChi: InChI=1S/C20H26N10O15P2/c21-19-25-13-7(15(34)27-19)23-3-29(13)17-10(32)9(31)5(43-17)1-42-47(39,40)45-12-6(2-41-46(36,37)38)44-18(11(12)33)30-4-24-8-14(30)26-20(22)28-16(8)35/h3-6,9-12,17-18,31-33H,1-2H2,(H,39,40)(H2,36,37,38)(H3,21,25,27,34)(H3,22,26,28,35)/t5-,6-,9-,10-,11-,12-,17-,18-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
5'-Phosphoguanylyl-(3',5')-guanosine reduces the rate of c-di-GMP degradation in cell lysates and inhibits the activity of EAL-dependent PDEs (PA2133, PvrR, and purified recombinant RocR) from P. aeruginosa.
Products are for research use only. Not for human use.
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