RMC-3943


Catalog No. Size PriceQuantity
M17849-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

RMC-3943 is an allosteric SHP2 inhibitor (inhibition of full-length SHP2 in biochemical assay, IC50 = 2.19 nM).

Product information

CAS Number: 1801764-60-2

Molecular Weight: 425.38

Formula: C18H22Cl2N6S

Chemical Name: (1R)-8-{6-amino-5-[(2, 3-dichloropyridin-4-yl)sulfanyl]pyrazin-2-yl}-8-azaspiro[4.5]decan-1-amine

Smiles: NC1=NC(=CN=C1SC1=CC=NC(Cl)=C1Cl)N1CCC2(CCC[C@H]2N)CC1

InChiKey: PSKJCIJLNDJVDV-GFCCVEGCSA-N

InChi: InChI=1S/C18H22Cl2N6S/c19-14-11(3-7-23-15(14)20)27-17-16(22)25-13(10-24-17)26-8-5-18(6-9-26)4-1-2-12(18)21/h3,7,10,12H,1-2,4-6,8-9,21H2,(H2,22,25)/t12-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

RMC-3943 inhibits pERK in PC9 cells, with an IC50 of 35.5 nM. RMC-3943 (0-10 μM) produces a concentration-dependent inhibition of proliferation of SK-MEL-113 cells.

Products are for research use only. Not for human use.

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