Description
RMC-3943 is an allosteric SHP2 inhibitor (inhibition of full-length SHP2 in biochemical assay, IC50 = 2.19 nM).
Product information
CAS Number: 1801764-60-2
Molecular Weight: 425.38
Formula: C18H22Cl2N6S
Chemical Name: (1R)-8-{6-amino-5-[(2, 3-dichloropyridin-4-yl)sulfanyl]pyrazin-2-yl}-8-azaspiro[4.5]decan-1-amine
Smiles: NC1=NC(=CN=C1SC1=CC=NC(Cl)=C1Cl)N1CCC2(CCC[C@H]2N)CC1
InChiKey: PSKJCIJLNDJVDV-GFCCVEGCSA-N
InChi: InChI=1S/C18H22Cl2N6S/c19-14-11(3-7-23-15(14)20)27-17-16(22)25-13(10-24-17)26-8-5-18(6-9-26)4-1-2-12(18)21/h3,7,10,12H,1-2,4-6,8-9,21H2,(H2,22,25)/t12-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
RMC-3943 inhibits pERK in PC9 cells, with an IC50 of 35.5 nM. RMC-3943 (0-10 μM) produces a concentration-dependent inhibition of proliferation of SK-MEL-113 cells.
Products are for research use only. Not for human use.
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