Description
C-7280948 is a selective and potent protein methyltransferase1 (PRMT1) inhibitor with an IC50 value of 12.75 μM.
Product information
CAS Number: 587850-67-7
Molecular Weight: 276.35
Formula: C14H16N2O2S
Chemical Name: 4-amino-N-(2-phenylethyl)benzene-1-sulfonamide
Smiles: NC1C=CC(=CC=1)S(=O)(=O)NCCC1C=CC=CC=1
InChiKey: BYWZPUPRVIECEC-UHFFFAOYSA-N
InChi: InChI=1S/C14H16N2O2S/c15-13-6-8-14(9-7-13)19(17,18)16-11-10-12-4-2-1-3-5-12/h1-9,16H,10-11,15H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : ≥ 38 mg/mL (137.51 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
C-7280948 is compound 6a in this article, it against hPRMT1 with an IC50 value of 12.75 μM. Especially arginine methyltransferases also target non-histone protein substrates and are therefore often called protein methyltransferases (PRMTs). The subtype PRMT1 has been linked to the activation of estrogen and androgen receptors and therefore may represent a new treatment option for hormone-dependent cancer.
Products are for research use only. Not for human use.
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