AMG-47a


Catalog No. Size PriceQuantity
M17892-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

AMG-47a is a potent and orally active lymphocyte-specific protein tyrosine kinase (Lck) inhibitor, with an IC50 of 0.2 nM. AMG-47a also inhibits VEGF2, p38α, Jak3 and MLR and IL-2 with IC50s of 1 nM, 3 nM, 72 nM, 30 nM and 21 nM, respectively. AMG-47a has anti-inflammatory activity.

Product information

CAS Number: 882663-88-9

Molecular Weight: 535.56

Formula: C29H28F3N5O2

Chemical Name: (Z)-4-methyl-3-[(2E)-2-{[2-(morpholin-4-yl)ethyl]imino}-2,3-dihydroquinazolin-6-yl]-N-[3-(trifluoromethyl)phenyl]benzene-1-carboximidic acid

Smiles: CC1C=CC(=CC=1C1=CC2=CN/C(/N=C2C=C1)=N\CCN1CCOCC1)/C(/O)=N/C1C=C(C=CC=1)C(F)(F)F

InChiKey: DVRSTRMZTAPMKO-UHFFFAOYSA-N

InChi: InChI=1S/C29H28F3N5O2/c1-19-5-6-21(27(38)35-24-4-2-3-23(17-24)29(30,31)32)16-25(19)20-7-8-26-22(15-20)18-34-28(36-26)33-9-10-37-11-13-39-14-12-37/h2-8,15-18H,9-14H2,1H3,(H,35,38)(H,33,34,36)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 34 mg/mL (63.48 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

You may also like

Recently viewed