KRAS G12C inhibitor 5


Catalog No. Size PriceQuantity
M17990-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

KRAS G12C inhibitor 5 is a KRas G12C inhibitor extracted from patent WO2017201161A1, Compound example 147.

Product information

CAS Number: 2158297-63-1

Molecular Weight: 551.68

Formula: C32H37N7O2

Chemical Name: 2-[(2S)-4-(2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-7-(naphthalen-1-yl)-5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-yl)-1-(prop-2-enoyl)piperazin-2-yl]acetonitrile

Smiles: CN1CCC[C@H]1COC1N=C2CN(CCC2=C(N=1)N1C[C@H](CC#N)N(CC1)C(=O)C=C)C1C=CC=C2C=CC=CC2=1

InChiKey: OBKBMFMBHWUYHS-DQEYMECFSA-N

InChi: InChI=1S/C32H37N7O2/c1-3-30(40)39-19-18-38(20-24(39)13-15-33)31-27-14-17-37(29-12-6-9-23-8-4-5-11-26(23)29)21-28(27)34-32(35-31)41-22-25-10-7-16-36(25)2/h3-6,8-9,11-12,24-25H,1,7,10,13-14,16-22H2,2H3/t24-,25-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Kirsten Rat Sarcoma 2 Viral Oncogene Homolog (KRas) is a small GTPase and a member of the Ras family of oncogenes. KRas serves a molecular switch cycling between inactive (GDP -bound) and active (GTP -bound) states to transduce upstream cellular signals received from multiple tyrosine kinases to downstream effectors to regulate a wide variety of processes, including cellular proliferation.

Products are for research use only. Not for human use.

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