Description
PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM. Anti-skin inflammatory activity.
Product information
CAS Number: 1892576-58-7
Molecular Weight: 497.51
Formula: C26H26F3N5O2
Chemical Name: 3-cyano-N-{1-methyl-3-[1-(2-methylpropanoyl)piperidin-4-yl]-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl}benzamide
Smiles: CN1C=C(C2CCN(CC2)C(=O)C(C)C)C2C1=NC=C(NC(=O)C1C=C(C=CC=1)C#N)C=2C(F)(F)F
InChiKey: BIHPJIJLDNUDGH-UHFFFAOYSA-N
InChi: InChI=1S/C26H26F3N5O2/c1-15(2)25(36)34-9-7-17(8-10-34)19-14-33(3)23-21(19)22(26(27,28)29)20(13-31-23)32-24(35)18-6-4-5-16(11-18)12-30/h4-6,11,13-15,17H,7-10H2,1-3H3,(H,32,35)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 41.67 mg/mL (83.76 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PF-06747711 (Compound 66) reduces IL-17 production by human Th17 cells with an IC50 of 9.5 nM.
In Vivo:
PF-06747711 (10, 30, and 100 mg/kg, p.o., daily over 5 days) inhibits ear swelling in a dose-dependent manner in mice.
Products are for research use only. Not for human use.
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