CU-CPT-9a


Catalog No. Size PriceQuantity
M18133-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5 nM.

Product information

CAS Number: 2165340-32-7

Molecular Weight: 265.31

Formula: C17H15NO2

Chemical Name: 4-(7-methoxyquinolin-4-yl)-2-methylphenol

Smiles: CC1C=C(C=CC=1O)C1=CC=NC2=CC(=CC=C12)OC

InChiKey: HNYBTVKYLVLWCB-UHFFFAOYSA-N

InChi: InChI=1S/C17H15NO2/c1-11-9-12(3-6-17(11)19)14-7-8-18-16-10-13(20-2)4-5-15(14)16/h3-10,19H,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 135 mg/mL (508.84 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5±0.1 nM. The elevation of the downstream protein levels induced by R848 can be reversed by CU-CPT-9a in a dose-dependent manner. By contrast, the expression of TRIF and IRF3 (cytoplasmic and nuclear) are only responsive to TLR4 and TLR3, independent of TLR837. The expression levels of TRIF and IRF3 do not show significant change in THP-1 cells upon treatment of R848, nor do they change with the treatment of CU-CPT-9a. CU-CPT8m and CU-CPT-9a both significantly suppress the TNF-α level in a dose-dependent manner, which is in agreement with previous reports of TLR8 involvement in these autoimmune diseases.

Products are for research use only. Not for human use.

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