Ac-CoA Synthase Inhibitor1


Catalog No. Size PriceQuantity
M18135-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Ac-CoA Synthase Inhibitor1 is a potent, reversible acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 of 0.6 µM. Ac-CoA Synthase Inhibitor1 inhibits the respiratory syncytial virus (RSV).

Product information

CAS Number: 508186-14-9

Molecular Weight: 410.51

Formula: C20H18N4O2S2

Chemical Name: 1-[2,3-bis(thiophen-2-yl)quinoxalin-6-yl]-3-(2-methoxyethyl)urea

Smiles: COCCNC(=O)NC1C=C2N=C(C(=NC2=CC=1)C1=CC=CS1)C1=CC=CS1

InChiKey: CTPVNWVUAGMHEJ-UHFFFAOYSA-N

InChi: InChI=1S/C20H18N4O2S2/c1-26-9-8-21-20(25)22-13-6-7-14-15(12-13)24-19(17-5-3-11-28-17)18(23-14)16-4-2-10-27-16/h2-7,10-12H,8-9H2,1H3,(H2,21,22,25)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 31.25 mg/mL (76.12 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Ac-CoA Synthase Inhibitor1 inhibits cellular [14C]acetate uptake into both lipids and histones with an IC50 of 5 µM. Ac-CoA Synthase Inhibitor1 inhibits the ability of HepG2 cells to incorporate [14C]acetate into lipids with IC50 of 6.8 µM. Ac-CoA Synthase Inhibitor1 inhibits HepG2 utilization of [14C]acetate for histone acetylation with IC50 of 5.5 µM.

Products are for research use only. Not for human use.

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