BM635


Catalog No. Size PriceQuantity
M18169-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

BM635 is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 has an MIC50 of 0.12 μM against M. tuberculosis H37Rv.

Product information

CAS Number: 1493762-74-5

Molecular Weight: 392.51

Formula: C25H29FN2O

Chemical Name: 4-{[1-(4-fluorophenyl)-2-methyl-5-[4-(propan-2-yl)phenyl]-1H-pyrrol-3-yl]methyl}morpholine

Smiles: CC1=C(CN2CCOCC2)C=C(C2C=CC(=CC=2)C(C)C)N1C1C=CC(F)=CC=1

InChiKey: NEEGNYKRJDHJNX-UHFFFAOYSA-N

InChi: InChI=1S/C25H29FN2O/c1-18(2)20-4-6-21(7-5-20)25-16-22(17-27-12-14-29-15-13-27)19(3)28(25)24-10-8-23(26)9-11-24/h4-11,16,18H,12-15,17H2,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 31 mg/mL (78.98 mM; Need ultrasonic and warming).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

BM635 has potent MIC (0.12 µM), Tox50:MIC ratio of >100, and good microsomal stability in mice (1.4 mL/min/g). When tested in an acute murine infection model at multiple doses, BM635 exhibits potent anti-tubercular activity, with an ED99 of 49 mg/Kg (IC95%: 43–54 mg/Kg). The half-life in vivo of BM635 is 1h, allowing a reasonable maximum concentration (Cmax=1.62 μM) and a moderate bioavailability (46%). Its poor aqueous solubility together with its high lipophilicity leads to low exposure in vivo.

Products are for research use only. Not for human use.

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