(3R, 4R)-A2-32-01

(3R,4R)-A2-32-01 (compound 2), an anti-virulence drug, is a specific caseinolytic protein proteases (ClpP) inhibitor with an EC50 of 4.5 μM, and shows a tolerable cytotoxicity.

Product information

CAS Number: 1359752-95-6

Molecular Weight: 301.42

Formula: C19H27NO2

Chemical Name: (3R,4R)-3-(non-8-en-1-yl)-4-[2-(pyridin-3-yl)ethyl]oxetan-2-one

Smiles: C=CCCCCCCC[C@@H]1[C@@H](CCC2C=NC=CC=2)OC1=O

InChiKey: WBHVHPLFRGISDD-QZTJIDSGSA-N

InChi: InChI=1S/C19H27NO2/c1-2-3-4-5-6-7-8-11-17-18(22-19(17)21)13-12-16-10-9-14-20-15-16/h2,9-10,14-15,17-18H,1,3-8,11-13H2/t17-,18-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 200 mg/mL (663.53 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

(3R,4R)-A2-32-01 inhibits hemolysis with an ED50 of 15 nmol on blood agar plates. (3R,4R)-A2-32-01 exhibits EC50s of 50 μM and 75 μM in dropping metabolic activity of NIH3T3 fibroblasts and HaCat keratinocytes, respectively.

Products are for research use only. Not for human use.