2-Iodomelatonin


Catalog No. Size PriceQuantity
M18204-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1 over MT2. 2-iodomelatonin can be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.

Product information

CAS Number: 93515-00-5

Molecular Weight: 358.17

Formula: C13H15IN2O2

Chemical Name: N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide

Smiles: CC(=O)NCCC1=C(I)NC2=CC=C(C=C12)OC

InChiKey: FJDDSMSDZHURBJ-UHFFFAOYSA-N

InChi: InChI=1S/C13H15IN2O2/c1-8(17)15-6-5-10-11-7-9(18-2)3-4-12(11)16-13(10)14/h3-4,7,16H,5-6H2,1-2H3,(H,15,17)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

2-iodomelatonin (0-7.5 μM; 18 hours) shares the protective properties of melatonin, it inhibits cell death of mutant htt ST14A and inhibits the increase in Rip2 expression in stressed mutant htt ST14A cells.

Products are for research use only. Not for human use.

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