Description
Isoconazole nitrate is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, exhibiting a rapid rate of absorption and low systemic exposure potential.
Product information
CAS Number: 24168-96-5
Molecular Weight: 479.14
Formula: C18H15Cl4N3O4
Chemical Name: 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1H-imidazole; nitric acid
Smiles: [O-][N+](O)=O.ClC1C=CC=C(Cl)C=1COC(CN1C=NC=C1)C1C=CC(Cl)=CC=1Cl
InChiKey: NNGQLSIGRSTLLU-UHFFFAOYSA-N
InChi: InChI=1S/C18H14Cl4N2O.HNO3/c19-12-4-5-13(17(22)8-12)18(9-24-7-6-23-11-24)25-10-14-15(20)2-1-3-16(14)21;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (208.71 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Isoconazole nitrate also exerts several other effects on the fungal membrane, which are independent of inhibition of the ergosterol synthesis. Isoconazole nitrate (ISN) causes a rapid reduction of cellular adenosine triphosphate (ATP) within 10 min of in vitro exposure. Isoconazole nitrate (1, 10 μg/mL) induces a blockade of cell division in vitro by its action on synthesis and organisation of the cell membrane. Isoconazole nitrate (50, 100 μg/mL), ISN induced necrosis and death of fungal cells.
Products are for research use only. Not for human use.
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