S-Nitroso-N-acetyl-DL-penicillamine


Catalog No. Size PriceQuantity
M18329-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a nitric oxide donor and acts as a stable inhibitor of platelet aggregation.

Product information

CAS Number: 67776-06-1

Molecular Weight: 220.25

Formula: C7H12N2O4S

Chemical Name: 2-acetamido-3-methyl-3-(nitrososulfanyl)butanoic acid

Smiles: CC(=O)NC(C(O)=O)C(C)(C)SN=O

InChiKey: ZIIQCSMRQKCOCT-UHFFFAOYSA-N

InChi: InChI=1S/C7H12N2O4S/c1-4(10)8-5(6(11)12)7(2,3)14-9-13/h5H,1-3H3,(H,8,10)(H,11,12)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (1135.07 mM; Need ultrasonic). H2O : 11.11 mg/mL (50.44 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

S-Nitroso-N-acetyl-DL-penicillamine (10 mM; 8 hours) induces toxicity of about 80% after 6 hours under normoxic conditions by releasing nitric oxide (NO). S-Nitroso-N-acetyl-DL-penicillamine has a half-time about 6 hours in in isolated rat ventricular myocytes. S-Nitroso-N-acetyl-DL-penicillamine (100 µM; 30 minutes) causes sustained decrease in the basal pHi in isolated rat ventricular myocytes.

In Vivo:

SNAP (100μM, 300μM) causes small but significant increases of the electrically evoked [3H]-acetylcholine release in guinea-pig tracheal.

Products are for research use only. Not for human use.

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