Description
Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na+/H+ exchange inhibitor.
Product information
CAS Number: 211813-86-4
Molecular Weight: 356.83
Formula: C14H17ClN4O3S
Chemical Name: N-carbamimidoyl-5-methanesulfonyl-2-methyl-4-(1H-pyrrol-1-yl)benzamide hydrochloride
Smiles: Cl.CC1=CC(=C(C=C1C(=O)NC(N)=N)S(C)(=O)=O)N1C=CC=C1
InChiKey: ORYLKKCAKGABAS-UHFFFAOYSA-N
InChi: InChI=1S/C14H16N4O3S.ClH/c1-9-7-11(18-5-3-4-6-18)12(22(2,20)21)8-10(9)13(19)17-14(15)16;/h3-8H,1-2H3,(H4,15,16,17,19);1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 55 mg/mL (154.14 mM; Need ultrasonic). H2O : 4.17 mg/mL (11.69 mM; ultrasonic and warming and heat to 60°C).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
There is no significant effects of the Na+/H+ exchange inhibitor eniporide on cardiac performance and high energy phosphate content in healthy pig hearts subjected to ischemia/reperfusion induced by crystalloid cardioplegic arrest.
In Vivo:
In stage 1, the administration of 100 mg and 150 mg eniporide results in smaller infarct sizes, especially in the angioplasty group. In contrast, in stage 2 there is no difference in the enzymatic infarct size between the three groups. Overall there is no effect of eniporide on clinical outcome (death, cardiogenic shock, heart failure, life-threatening arrhythmias). However, there is a significant reduction of the incidence of heart failure in patients reperfused late (>4 h).
Products are for research use only. Not for human use.
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