Description
Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist, with anti-myopia effect. Atropine blocks the inhibitory effect of ACh on heart rate and contractility, potentially also leading to tachyarrhythmias.
Product information
CAS Number: 51-55-8
Molecular Weight: 289.37
Formula: C17H23NO3
Chemical Name: Benzeneacetic acid, alpha-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
Smiles: CN1[C@@H]2C[C@H](C[C@H]1CC2)OC(=O)C(CO)C1C=CC=CC=1 |&1:2,4,6|
InChiKey: RKUNBYITZUJHSG-SPUOUPEWSA-N
InChi: InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : ≥ 96.6 mg/mL (333.83 mM). H2O : 2.9 mg/mL (10.02 mM; Need ultrasonic and warming).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Atropine increases cAMP independently of M1/2/3-muscarinic receptors in cardiomyocytes. Atropine inhibits the cAMP-specific phosphodiesterase PDE4 in cardiomyocytes. Atropine might inhibit myopia via α2A-adrenoceptors, , instead of through the mAChR M4/cM4 receptor subtype.
In Vivo:
Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4 (PDE4). Atropine (30-60 mg/kg/day; s.c.) causes changes in mouse motility that is not correlates to its modification of ACh levels in the CNS.
Products are for research use only. Not for human use.
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