D159687


Catalog No. Size PriceQuantity
M18564-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

D159687 is a selective PDE4D inhibitor.

Product information

CAS Number: 1155877-97-6

Molecular Weight: 366.84

Formula: C21H19ClN2O2

Chemical Name: [4-({3'-chloro-6-methoxy-[1,1'-biphenyl]-3-yl}methyl)phenyl]urea

Smiles: COC1C=CC(CC2C=CC(=CC=2)NC(N)=O)=CC=1C1=CC(Cl)=CC=C1

InChiKey: RJJLUTWHJUDZFP-UHFFFAOYSA-N

InChi: InChI=1S/C21H19ClN2O2/c1-26-20-10-7-15(12-19(20)16-3-2-4-17(22)13-16)11-14-5-8-18(9-6-14)24-21(23)25/h2-10,12-13H,11H2,1H3,(H3,23,24,25)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 150 mg/mL (408.90 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment. D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM.

In Vivo:

D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques.

Products are for research use only. Not for human use.

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