Description
D159687 is a selective PDE4D inhibitor.
Product information
CAS Number: 1155877-97-6
Molecular Weight: 366.84
Formula: C21H19ClN2O2
Chemical Name: [4-({3'-chloro-6-methoxy-[1,1'-biphenyl]-3-yl}methyl)phenyl]urea
Smiles: COC1C=CC(CC2C=CC(=CC=2)NC(N)=O)=CC=1C1=CC(Cl)=CC=C1
InChiKey: RJJLUTWHJUDZFP-UHFFFAOYSA-N
InChi: InChI=1S/C21H19ClN2O2/c1-26-20-10-7-15(12-19(20)16-3-2-4-17(22)13-16)11-14-5-8-18(9-6-14)24-21(23)25/h2-10,12-13H,11H2,1H3,(H3,23,24,25)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 150 mg/mL (408.90 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment. D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM.
In Vivo:
D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques.
Products are for research use only. Not for human use.
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