HA130


Catalog No. Size PriceQuantity
M18566-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM.

Product information

CAS Number: 1229652-21-4

Molecular Weight: 463.29

Formula: C24H19BFNO5S

Chemical Name: (3-{[4-({3-[(4-fluorophenyl)methyl]-2, 4-dioxo-1, 3-thiazolidin-5-ylidene}methyl)phenoxy]methyl}phenyl)boronic acid

Smiles: OB(O)C1=CC(COC2C=CC(C=C3SC(=O)N(CC4C=CC(F)=CC=4)C3=O)=CC=2)=CC=C1

InChiKey: VTNKMYWFWQTEHE-XKZIYDEJSA-N

InChi: InChI=1S/C24H19BFNO5S/c26-20-8-4-17(5-9-20)14-27-23(28)22(33-24(27)29)13-16-6-10-21(11-7-16)32-15-18-2-1-3-19(12-18)25(30)31/h1-13,30-31H,14-15H2/b22-13-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 39 mg/mL (84.18 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation.

In Vivo:

HA130 slows T cell migration across lymph node HEVs. HA130 decreases the "outside HEVs/inside HEVs" ratio by 3-4-fold compared to vehicle-treated animals vehicle. The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs).

Products are for research use only. Not for human use.

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