Description
SB 258719 is a selective 5-HT7 receptor antagonist displayed high affnity (pKi=7.5) for the receptor. SB-258719 shows apparent partial inverse agonism.
Product information
CAS Number: 195199-95-2
Molecular Weight: 338.51
Formula: C18H30N2O2S
Chemical Name: N,3-dimethyl-N-[(2R)-4-(4-methylpiperidin-1-yl)butan-2-yl]benzene-1-sulfonamide
Smiles: CN([C@H](C)CCN1CCC(C)CC1)S(=O)(=O)C1C=C(C)C=CC=1
InChiKey: AGVNHDNTFYHZNL-QGZVFWFLSA-N
InChi: InChI=1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3/t17-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 250 mg/mL (738.53 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
SB 258719 (1, 3 and 10 μM; HEK 293 cells) produces a concentration-related rightward-shift of the 5-CT concentration-response curve with no signifcant alteration in the maximal response to 5-CT.
In Vivo:
SB 258719 (5~20 mg/kg; i.p.) significantly attenuates the 5-CT-induced hypothermia.
Products are for research use only. Not for human use.
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