Acriflavine


Catalog No. Size PriceQuantity
M18587-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Acriflavine is a fluorescent dye for labeling high molecular weight RNA. It is also a topical antiseptic.

Product information

CAS Number: 8048-52-0

Molecular Weight: 468.98

Formula: C27H25ClN6

Chemical Name: 3,6-diamino-10-methylacridin-10-ium acridine-3,6-diamine chloride

Smiles: [Cl-].C[N+]1=C2C=C(N)C=CC2=CC2C=CC(N)=CC1=2.NC1=CC2N=C3C=C(N)C=CC3=CC=2C=C1

InChiKey: PEJLNXHANOHNSU-UHFFFAOYSA-N

InChi: InChI=1S/C14H13N3.C13H11N3.ClH/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;/h2-8H,1H3,(H3,15,16);1-7H,14-15H2;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : ≥ 25 mg/mL (96.25 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Acriflavine is identified as a potent inhibitor of the MCT4 that can inhibit the binding between Basigin and MCT4. Acriflavine significantly inhibits growth and self-renewal potential of several glioblastoma neurosphere lines. The HIF-1 inhibitor acriflavine decreases survival and growth of CML cells. It targets stem cell potential of CML cells.

In Vivo:

Acriflavine treatment inhibits intratumoral expression of VEGF and tumor vascularization. In a murine CML model, acriflavine decreases leukemia development and reduces LSC maintenance. Acriflavine retards tumor growth in a murine model of breast cancer. The combination of sunitinib with acriflavine significantly decreases vascular endothelial growth factor and TGF-β expression and reduces tumor vasculature followed by increased intratumor necrosis and apoptosis.

Products are for research use only. Not for human use.

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