Description
Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors.
Product information
CAS Number: 58-63-9
Molecular Weight: 268.23
Formula: C10H12N4O5
Chemical Name: 9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-3H-purin-6-one
Smiles: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2C(=O)N=CNC1=2
InChiKey: UGQMRVRMYYASKQ-KQYNXXCUSA-N
InChi: InChI=1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)/t4-,6-,7-,10-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 25 mg/mL (93.20 mM; Need ultrasonic). H2O : 10 mg/mL (37.28 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Inosine dose-dependently stimulates cAMP production mediated through the A2AR. Inosine dose-dependently induces hA2AR-mediated ERK1/2 phosphorylation. Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes.
In Vivo:
Inosine (10-100 mg/kg; i.p.) exhibits antinociceptive effect in mice.
Products are for research use only. Not for human use.
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