Description
PL-017 is a potent and selective μ opioid receptor agonist with an IC50 of 5.5 nM for 125I-FK 33,824 binding to μ site. PL-017 produces long-lasting, reversible analgesia in rats.
Product information
CAS Number: 83397-56-2
Molecular Weight: 535.63
Formula: C29H37N5O5
Chemical Name: (2R)-1-[(2S)-2-{1-[(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidin-2-yl]-N-methylformamido}-3-phenylpropanoyl]pyrrolidine-2-carboxamide
Smiles: CN([C@@H](CC1C=CC=CC=1)C(=O)N1CCC[C@@H]1C(N)=O)C(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CC1C=CC(O)=CC=1
InChiKey: JAKBYSTWCHUQOK-NDBXHCKUSA-N
InChi: InChI=1S/C29H37N5O5/c1-32(25(18-19-7-3-2-4-8-19)29(39)33-15-5-9-23(33)26(31)36)28(38)24-10-6-16-34(24)27(37)22(30)17-20-11-13-21(35)14-12-20/h2-4,7-8,11-14,22-25,35H,5-6,9-10,15-18,30H2,1H3,(H2,31,36)/t22-,23+,24-,25-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PL-017 has an IC50 of 10000 nM for 125I-DADLE binding to δ site.
In Vivo:
PL-017 (0.22, 0.45, 0.9 nmol/rat; i.c.v.) has the time of maximum effect of approximately 15 to 30 mm after injection at lower doses and produces analgesia lasting as long as 4 hours with larger doses in male Sprague-Dawley rats weighing 250 to 375 g.
Products are for research use only. Not for human use.
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