Description
L-690330 is a competitive inhibitor of inositol monophosphatase (IMPase) with Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 exhibits 10-fold more sensitive than mouse and rat IMPase.
Product information
CAS Number: 142523-38-4
Molecular Weight: 298.12
Formula: C8H12O8P2
Chemical Name: [1-(4-hydroxyphenoxy)-1-phosphonoethyl]phosphonic acid
Smiles: CC(OC1=CC=C(O)C=C1)(P(O)(O)=O)P(O)(O)=O
InChiKey: JKOCAAWWDVHWKB-UHFFFAOYSA-N
InChi: InChI=1S/C8H12O8P2/c1-8(17(10,11)12,18(13,14)15)16-7-4-2-6(9)3-5-7/h2-5,9H,1H3,(H2,10,11,12)(H2,13,14,15)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 25 mg/mL (83.86 mM; Need ultrasonic). H2O : 33.33 mg/mL (111.80 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
L-690330 (50 μM; 1 hour) induces P-AMPK and autophagy and increases LC3-I/II and p-AMPK expression in HEK293 cells.
In Vivo:
L-690330 (intracerebroventricular injection; 0.1 μmol) has no effects on their motor activity and coordination in the beam walking, except a reduction in time spent in light in the dark/light test.
Products are for research use only. Not for human use.
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