Dihomo-γ-linolenic acid


Catalog No. Size PriceQuantity
M18740-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system.

Product information

CAS Number: 1783-84-2

Molecular Weight: 306.48

Formula: C20H34O2

Chemical Name: (8Z,11Z,14Z)-icosa-8,11,14-trienoic acid

Smiles: CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(O)=O

InChiKey: HOBAELRKJCKHQD-QNEBEIHSSA-N

InChi: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Dihomo-γ-linolenic acid attenuates pro-inflammatory gene expression in human and mouse macrophages. Dihomo-γ-linolenic acid (50 μM; 24 hours) attenuates IFN-γ induced phosphorylation of STAT1 on serine 727. Dihomo-γ-linolenic acid attenuates IL-1β and TNF-α induced MCP-1 and ICAM-1 expression in human macrophages. Dihomo-γ-linolenic acid attenuates chemokine-driven monocytic migration and macrophage foam cell formation. Dihomo-γ-linolenic acid attenuates the expression of SR-A and CD36 in human macrophages. Dihomo-γ-linolenic acid modulates mitochondrial respiration. Dihomo-γ-linolenic acid modulates the properties of endothelial cells and VSMC.

In Vivo:

Dihomo-γ-linolenic acid (8 mg/mouse; i.g; twice a week; for 35 days) inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA.

Products are for research use only. Not for human use.

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