Description
Clopamide is an orally active thiazide-like diuretic agent that inhibits the sodium-coupled chloride cotransporter SLC12A3. Clopamide has the potential for hypertension and cardiac failure research.
Product information
CAS Number: 636-54-4
Molecular Weight: 345.84
Formula: C14H20ClN3O3S
Chemical Name: 4-chloro-N-[(2R,6S)-2,6-dimethylpiperidin-1-yl]-3-sulfamoylbenzamide
Smiles: C[C@@H]1CCC[C@H](C)N1NC(=O)C1C=C(C(Cl)=CC=1)S(N)(=O)=O
InChiKey: LBXHRAWDUMTPSE-AOOOYVTPSA-N
InChi: InChI=1S/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21)/t9-,10+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 250 mg/mL (722.88 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Clopamide is actively secreted by renal tubular cells and the True Tubular Excretion Fraction (TTEF) value is 10%.
In Vivo:
The venoconstrictor response to bradykinin is attenuated after oral administration of Clopamide (0.5 mg/kg), and by concomitant local infusion of cyclosporine-A (1-10 μg/min) in conscious dogs.
Products are for research use only. Not for human use.
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