COX-2-IN-2


Catalog No. Size PriceQuantity
M18764-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

COX-2-IN-2 is a selective and inducible COX2 inhibitor with an IC50 of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compound with anti-inflammatory and analgesic activities.

Product information

CAS Number: 134729-13-8

Molecular Weight: 341.36

Formula: C17H12FN3O2S

Chemical Name: 1-(4-fluorophenyl)-5-(4-methanesulfonylphenyl)-1H-pyrazole-3-carbonitrile

Smiles: CS(=O)(=O)C1C=CC(=CC=1)C1=CC(C#N)=NN1C1C=CC(F)=CC=1

InChiKey: NKBRWXWNSUIHNI-UHFFFAOYSA-N

InChi: InChI=1S/C17H12FN3O2S/c1-24(22,23)16-8-2-12(3-9-16)17-10-14(11-19)20-21(17)15-6-4-13(18)5-7-15/h2-10H,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

COX-2-IN-2 shows no COX-1 inhibition even at 100μM.

In Vivo:

COX-2-IN-2 has oral ED50 values of 0.030 and 0.47mg/kg on adjuvant-induced arthritis and collagen-induced arthritis, respectively, and an ED30 value of 7.4mg/kg in the yeast-induced hyperalgesia (Randall-Selitto) assay. COX-2-IN-2 shows good analgesic activity and no ulcerogenicity.

Products are for research use only. Not for human use.

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