Description
Arterolane is an antimalarial agent, with IC50 of both 1.1 nM against P. falciparum Ro73 and W2, respectively.
Product information
CAS Number: 664338-39-0
Molecular Weight: 392.53
Formula: C22H36N2O4
Chemical Name: N-(2-amino-2-methylpropyl)-2-[(1R,3S,4's,4''s,5R,7S)-dispiro[adamantane-2,2'-[1,3,5]trioxolane-4',1''-cyclohexan]-4''-yl]acetamide
Smiles: CC(C)(N)CNC(=O)C[C@@H]1CC[C@@]2(CC1)OO[C@]1(O2)[C@@H]2C[C@H]3C[C@H](C[C@@H]1C3)C2
InChiKey: VXYZBLXGCYNIHP-SSPKTAKCSA-N
InChi: InChI=1S/C22H36N2O4/c1-20(2,23)13-24-19(25)12-14-3-5-21(6-4-14)26-22(28-27-21)17-8-15-7-16(10-17)11-18(22)9-15/h14-18H,3-13,23H2,1-2H3,(H,24,25)/t14-,15-,16+,17-,18+,21+,22-
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (254.76 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Arterolane (Trioxolane 7; OZ277; RBx-11160) is an antimalarial agent, with IC50s of both 1.1 nM (0.43 ng/mL) against P. falciparum Ro73 and W2, respectively. Arterolane also shows inhibitory activity against several other P. falciparums, with IC50s of 1.0, 1.6, 0.90, 0.91, 1.4, 1.5, 0.83, and 0.84 ng/mL for P. falciparum K1, Fc27, FVO, NF54, HB3, FCB1, ITG2-F6, and MAD20, respectively.
Products are for research use only. Not for human use.
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