GPR40 agonist 4


Catalog No. Size PriceQuantity
M18809-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

GPR40 agonist 4 is a potent free fatty acid receptor 1 (FFA1/ GPR40) agonist with a pEC50 of 7.54.

Product information

CAS Number: 2102196-57-4

Molecular Weight: 416.87

Formula: C21H17ClO5S

Chemical Name: 2-[4-({2'-chloro-[1,1'-biphenyl]-3-yl}methoxy)benzenesulfonyl]acetic acid

Smiles: OC(=O)CS(=O)(=O)C1C=CC(=CC=1)OCC1C=C(C=CC=1)C1=CC=CC=C1Cl

InChiKey: YEFZZALZTNOYEA-UHFFFAOYSA-N

InChi: InChI=1S/C21H17ClO5S/c22-20-7-2-1-6-19(20)16-5-3-4-15(12-16)13-27-17-8-10-18(11-9-17)28(25,26)14-21(23)24/h1-12H,13-14H2,(H,23,24)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 160 mg/mL (383.81 mM; Need ultrasonic and warming).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

GPR40 agonist 4 tends to have a low risk of activating caspase-3/7.

In Vivo:

Single oral administration of GPR40 agonist 4 (compound 20) robustly reduces the plasma glucose excursion and enhances insulin secretion during an oral glucose tolerance test (OGTT) in a dose-dependent manner from 1 to 10 mg/kg when GPR40 agonist 4 is dosed 60 min prior to the oral glucose challenge. The area under the curve of blood glucose (AUC0-120min) and blood insulin (AUC0-120min) reveal that the minimum effective dose of GPR40 agonist 4 is 3 mg/kg. The hyperglycemia state is also markedly improved in GPR40 agonist 4 (20 mg/kg) treated group.

Products are for research use only. Not for human use.

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