Description
Ertapenem sodium (L-749345), a long-acting Carbapenem, is a β-lactam antibiotic with a broad antibacterial spectrum. Ertapenem sodium is active against both Gram-positive and Gram-negative bacteria, including Enterobacteriaceae, Streptococcus pneumoniae and most species of anaerobic bacteria.
Product information
CAS Number: 153773-82-1
Molecular Weight: 497.50
Formula: C22H24N3NaO7S
Chemical Name: sodium 3-[(2S,4S)-4-{[(4R,5S,6S)-2-carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]sulfanyl}pyrrolidine-2-amido]benzoate
Smiles: [Na+].C[C@@H]1[C@@H]2[C@@H]([C@@H](C)O)C(=O)N2C(=C1S[C@@H]1CN[C@@H](C1)C(=O)NC1C=C(C=CC=1)C([O-])=O)C(O)=O
InChiKey: ZXNAQFZBWUNWJM-HRXMHBOMSA-M
InChi: InChI=1S/C22H25N3O7S.Na/c1-9-16-15(10(2)26)20(28)25(16)17(22(31)32)18(9)33-13-7-14(23-8-13)19(27)24-12-5-3-4-11(6-12)21(29)30;/h3-6,9-10,13-16,23,26H,7-8H2,1-2H3,(H,24,27)(H,29,30)(H,31,32);/q;+1/p-1/t9-,10-,13+,14+,15-,16-;/m1./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: H2O : 62.5 mg/mL (125.63 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Ertapenem sodium inhibits Streptococcus pneumoniae with MIC50s values < 1mg/L. Ertapenem sodium exhibits a bactericidal mode of action as shown by time-killing curves and exhibits a short postantibiotic effect (PAE) of 1.4-2.6 h against the Gram-positive strains but no PAE against Gram-negative strains.
In Vivo:
Ertapenem sodium (50 mg/kg; s.c.; q6h; for 24 hours) shows substantial bactericidal activity against S. pneumoniae in the murine thigh infection model. Ertapenem sodium exhibits an AUC0-24 of 586 mg•h/L, Cmax of 140 mg/L following subcutaneous injection (mice 50 mg/kg).
Products are for research use only. Not for human use.
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