Description
Aucubin, an iridoid glucoside, is isolated from Plantago asiatica, Eucommia ulmoides, the leaves of Aucuba japonica and more recently from butterfly larva. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects.
Product information
CAS Number: 479-98-1
Molecular Weight: 346.33
Formula: C15H22O9
Chemical Name: 2-{[5-hydroxy-7-(hydroxymethyl)-1H,4aH,5H,7aH-cyclopenta[c]pyran-1-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
Smiles: OC1C=C(CO)C2C(OC3OC(CO)C(O)C(O)C3O)OC=CC12
InChiKey: RJWJHRPNHPHBRN-UHFFFAOYSA-N
InChi: InChI=1S/C15H22O9/c16-4-6-3-8(18)7-1-2-22-14(10(6)7)24-15-13(21)12(20)11(19)9(5-17)23-15/h1-3,7-21H,4-5H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (288.74 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Aucubin (0.001-1 μg/mL; pretreated for 30 min) dose-dependently inhibits IgE-induced TNF-α and IL-6 production and expression in RBL-2H3 cells, with IC50s of 0.101 and 0.19 μg/mL, respectively. Aucubin (0.01 μg/mL; pretreated for 30 min) inhibits IgE-induced nuclear translocation of p65 subunit of NF-κB and degradation of IκBα in RBL-2H3 cells. Aucubin (0.001-1 mM; 12 h) increases PC12 cellular viability and markedly inhbits H2O2-induced apoptotic cell death.
In Vivo:
Aucubin (5 mg/kg; i.p. for 15 d) has antioxidant and pancreas-protective effects on rats with streptozotocin-induced diabetes. Aucubin (40-200 mg/kg; a single i.p.) exhibits significant protective activity against α-amanitin intoxication in mice. Aucubin (5 mg/kg/day; i.p. for 21 d) decreases the breathing frequency, increases the lung dynamic compliance, alleviates lung parenchymal fibrotic changes, and reduces the intrapulmonary collagen disposition and inflammatory injury of BLM-stimulated mice.
Products are for research use only. Not for human use.
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