Gap19


Catalog No. Size PriceQuantity
M18924-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial.

Product information

CAS Number: 1507930-57-5

Molecular Weight: 1161.44

Formula: C55H96N14O13

Chemical Name: (2S)-6-amino-2-[(Z)-[(2S)-2-[(Z)-[(2S)-6-amino-2-[(Z)-[(2S)-6-amino-2-[(Z)-[(2S,3S)-2-[(Z)-[(2S)-4-carboxy-2-[(Z)-[(2S,3S)-2-[(Z)-[(2S)-2-[(Z)-[(2S)-2,6-diamino-1-hydroxyhexylidene]amino]-1-hydroxy-4-(C-hydroxycarbonimidoyl)butylidene]amino]-1-hydroxy-3-methylpentylidene]amino]-1-hydroxybutylidene]amino]-1-hydroxy-3-methylpentylidene]amino]-1-hydroxyhexylidene]amino]-1-hydroxyhexylidene]amino]-1-hydroxy-3-phenylpropylidene]amino]hexanoic acid

Smiles: C[C@@H](CC)[C@H](/N=C(\O)/[C@H](CCC(O)=O)/N=C(\O)/[C@@H](/N=C(\O)/[C@H](CCC(=N)O)/N=C(\O)/[C@@H](N)CCCCN)[C@@H](C)CC)/C(/O)=N/[C@@H](CCCCN)/C(/O)=N/[C@@H](CCCCN)/C(/O)=N/[C@@H](CC1C=CC=CC=1)/C(/O)=N/[C@@H](CCCCN)C(O)=O

InChiKey: IEAKEKFIXUZWEH-PKMKMBMKSA-N

InChi: InChI=1S/C55H96N14O13/c1-5-33(3)45(69-51(77)40(25-27-44(71)72)65-54(80)46(34(4)6-2)68-50(76)39(24-26-43(61)70)62-47(73)36(60)20-10-14-28-56)53(79)64-38(22-12-16-30-58)48(74)63-37(21-11-15-29-57)49(75)67-42(32-35-18-8-7-9-19-35)52(78)66-41(55(81)82)23-13-17-31-59/h7-9,18-19,33-34,36-42,45-46H,5-6,10-17,20-32,56-60H2,1-4H3,(H2,61,70)(H,62,73)(H,63,74)(H,64,79)(H,65,80)(H,66,78)(H,67,75)(H,68,76)(H,69,77)(H,71,72)(H,81,82)/t33-,34-,36-,37-,38-,39-,40-,41-,42-,45-,46-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Gap19 (250 μM; for 30 min ) decreases mitochondrial potassium uptake. Gap19 (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells. Gap19 (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes. Gap19 (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo.

In Vivo:

Gap19 (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth.

Products are for research use only. Not for human use.

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