Description
Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer.
Product information
CAS Number: 55916-51-3
Molecular Weight: 736.93
Formula: C40H64O12
Chemical Name: (1S,2S,3S,4R,6S)-4-{[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[(1'R,2R,2'R,4'S,5R,7'S,8'S,9'S,12'S,13'R,16'R)-5,7',9',13'-tetramethyl-5'-oxaspiro[oxane-2,6'-pentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosan]-18'-en-8'-oloxy]oxan-3-yl]oxy}-6-methylcyclohexane-1,2,3-triol
Smiles: C[C@]12CC[C@H](CC1=CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@@H]1C[C@@H]1O[C@]3(CC[C@@H](C)CO3)[C@@H](C)[C@]21O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[C@@H]1C[C@H](C)[C@H](O)[C@H](O)[C@@H]1O
InChiKey: MSOCRRNEUZGEBR-LRAIPUAWSA-N
InChi: InChI=1S/C40H64O12/c1-19-8-13-39(48-18-19)21(3)40(47)29(52-39)16-26-24-7-6-22-15-23(9-11-37(22,4)25(24)10-12-38(26,40)5)49-36-35(34(46)32(44)28(17-41)51-36)50-27-14-20(2)30(42)33(45)31(27)43/h6,19-21,23-36,41-47H,7-18H2,1-5H3/t19-,20+,21-,23-,24-,25+,26-,27-,28-,29+,30+,31-,32-,33+,34+,35-,36-,37+,38+,39-,40-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (135.34 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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