DC_517


Catalog No. Size PriceQuantity
M18980-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 1.7 μM and 0.91 μM, respectively.

Product information

CAS Number: 500017-70-9

Molecular Weight: 505.65

Formula: C33H35N3O2

Chemical Name: (3-{[1,3-bis(9H-carbazol-9-yl)propan-2-yl]oxy}-2-hydroxypropyl)(propan-2-yl)amine

Smiles: CC(C)NCC(O)COC(CN1C2C=CC=CC=2C2=CC=CC=C12)CN1C2C=CC=CC=2C2=CC=CC=C12

InChiKey: BLTONWSCODZCNA-UHFFFAOYSA-N

InChi: InChI=1S/C33H35N3O2/c1-23(2)34-19-24(37)22-38-25(20-35-30-15-7-3-11-26(30)27-12-4-8-16-31(27)35)21-36-32-17-9-5-13-28(32)29-14-6-10-18-33(29)36/h3-18,23-25,34,37H,19-22H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 50 mg/mL (98.88 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 1.7 μM and 0.91 μM, respectively. DC_517 (1.25, 2.5, 5, and 10 μM) potently inhibits the proliferation of HCT116 (human colon cancer) and Capan-1 (human pancreatic adenocarcinoma cells) after treatment for 24, 48, and 72 h. DC_517 (0, 0.75, 1.5, and 3 μM) also dose-dependently induces apoptotic cell death in HCT116 cells.

Products are for research use only. Not for human use.

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