Gboxin


Catalog No. Size PriceQuantity
M19045-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Gboxin is an oxidative phosphorylation (OXPHOS) inhibitor that targets glioblastoma. Gboxin inhibits the activity of F0F1 ATP synthase. Antitumour activity.

Product information

CAS Number: 2101315-36-8

Molecular Weight: 392.96

Formula: C22H33ClN2O2

Chemical Name: 2-ethyl-3-methyl-1-(2-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxoethyl)-1H-1,3-benzodiazol-3-ium chloride

Smiles: [Cl-].CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)CN1C(CC)=[N+](C)C2=CC=CC=C12

InChiKey: UBWVTCCKVGOTBG-VYZBTARASA-M

InChi: InChI=1S/C22H33N2O2.ClH/c1-6-21-23(5)18-9-7-8-10-19(18)24(21)14-22(25)26-20-13-16(4)11-12-17(20)15(2)3;/h7-10,15-17,20H,6,11-14H2,1-5H3;1H/q+1;/p-1/t16-,17+,20-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 32.5 mg/mL (82.71 mM; Need ultrasonic). H2O : 10 mg/mL (25.45 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Gboxin (0-15 μM; 96 hours) specifically inhibit the growth of primary ‘high-throughput GBM sphere’ (HTS) cells but not that of cycling primary low-passage mouse embryonic fibroblasts (MEFs) or astrocytes.

Products are for research use only. Not for human use.

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