IX 207-887


Catalog No. Size PriceQuantity
M19277-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

IX 207-887 is a novel antiarthritic agent which inhibits the release of interleukin-1 (IL-1).

Product information

CAS Number: 98320-39-9

Molecular Weight: 284.33

Formula: C16H12O3S

Chemical Name: 2-[(2Z)-8-methoxy-6-thiatricyclo[8.4.0.0³,⁷]tetradeca-1(10),3(7),4,8,11,13-hexaen-2-ylidene]acetic acid

Smiles: COC1=CC2C=CC=CC=2/C(=C/C(O)=O)/C2C=CSC=21

InChiKey: XIKRQPKFOKKGGW-LCYFTJDESA-N

InChi: InChI=1S/C16H12O3S/c1-19-14-8-10-4-2-3-5-11(10)13(9-15(17)18)12-6-7-20-16(12)14/h2-9H,1H3,(H,17,18)/b13-9-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

IX 207-887 is a novel antiarthritic agent which inhibits the release of interleukin-1 (IL-1) from human monocytes and mouse peritoneal macrophages. In all test systems IX 207-887 significantly reduces both biologically active and immunoreactive IL-1 in culture media, whereas the levels of IL-1 in homogenates or lysates are either unaffected or only marginally reduced. IX 207-887 neither affects the adherence of human monocytes nor markedly inhibits IL-1 or IL-2-induced thymocyte proliferation. In the chondrocyte test no IL-1 antagonistic activity of IX 207-887 can be observed.

Products are for research use only. Not for human use.

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