Description
IX 207-887 is a novel antiarthritic agent which inhibits the release of interleukin-1 (IL-1).
Product information
CAS Number: 98320-39-9
Molecular Weight: 284.33
Formula: C16H12O3S
Chemical Name: 2-[(2Z)-8-methoxy-6-thiatricyclo[8.4.0.0³,⁷]tetradeca-1(10),3(7),4,8,11,13-hexaen-2-ylidene]acetic acid
Smiles: COC1=CC2C=CC=CC=2/C(=C/C(O)=O)/C2C=CSC=21
InChiKey: XIKRQPKFOKKGGW-LCYFTJDESA-N
InChi: InChI=1S/C16H12O3S/c1-19-14-8-10-4-2-3-5-11(10)13(9-15(17)18)12-6-7-20-16(12)14/h2-9H,1H3,(H,17,18)/b13-9-
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
IX 207-887 is a novel antiarthritic agent which inhibits the release of interleukin-1 (IL-1) from human monocytes and mouse peritoneal macrophages. In all test systems IX 207-887 significantly reduces both biologically active and immunoreactive IL-1 in culture media, whereas the levels of IL-1 in homogenates or lysates are either unaffected or only marginally reduced. IX 207-887 neither affects the adherence of human monocytes nor markedly inhibits IL-1 or IL-2-induced thymocyte proliferation. In the chondrocyte test no IL-1 antagonistic activity of IX 207-887 can be observed.
Products are for research use only. Not for human use.
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