Qc1


Catalog No. Size PriceQuantity
M19287-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Qc1 is a reversible and noncompetitive threonine dehydrogenase (TDH) inhibitor. Qc1 can be used for the research of Metabolic disease.

Product information

CAS Number: 403718-45-6

Molecular Weight: 455.45

Formula: C23H16F3N3O2S

Chemical Name: (4aS)-N-benzyl-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-2,3,4,4a-tetrahydroquinazoline-7-carboxamide

Smiles: O=C1[C@H]2C=CC(=CC2=NC(=S)N1C1C=C(C=CC=1)C(F)(F)F)C(=O)NCC1C=CC=CC=1

InChiKey: LZLMIOJNWWPRIZ-SFHVURJKSA-N

InChi: InChI=1S/C23H16F3N3O2S/c24-23(25,26)16-7-4-8-17(12-16)29-21(31)18-10-9-15(11-19(18)28-22(29)32)20(30)27-13-14-5-2-1-3-6-14/h1-12,18H,13H2,(H,27,30)/t18-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Qc1 (10 μM; 2~24 hours; ES cells) shows that a substantial fraction of the total LC3 protein is in the LC3-I (cytoplasmic) form. After 16 h of TDH inhibition, most LC3 is converted to the LC3-II (lipid-modified) form, indicative of increased autophagic activity. . Qc1 blocks the charging of tetrahydrofolate. Qc1 prevents threonine dehydrogenase from catabolizing threonine into acetyl-CoA and glycine.

Products are for research use only. Not for human use.

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