Pseudothymidine


Catalog No. Size PriceQuantity
M19387-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Pseudothymidine is a C-nucleoside analog of thymidine.

Product information

CAS Number: 65358-15-8

Molecular Weight: 242.23

Formula: C10H14N2O5

Chemical Name: 5-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Smiles: CN1C=C([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC1=O

InChiKey: AMDJRICBYOAHBZ-XLPZGREQSA-N

InChi: InChI=1S/C10H14N2O5/c1-12-3-5(9(15)11-10(12)16)7-2-6(14)8(4-13)17-7/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 61.17 mg/mL (252.53 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Pseudothymidine is a C-nucleoside analog of thymidine. The calculated ΔΔG°50/mod is -0.5 kcal/mol, with a ΔTm/mod of 0.82°C. For the duplexes containing nine dA-T/ψT pairs, the ΔTm/mod is -0.9°C and a ΔΔG°50/mod is +1.1 kcal/mol. The modification of the duplex containing 12 consecutive dA-T/ψT base pairs produces a ΔTm/mod of -0.9°C and a ΔΔG°50/mod of +1.2 kcal/mol.

Products are for research use only. Not for human use.

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