Description
SA72 is a highly selective fatty acid amide hydrolase (FAAH) inhibitor.
Product information
CAS Number: 934809-60-6
Molecular Weight: 402.44
Formula: C21H26N2O6
Chemical Name: carbamoylmethyl N-{3-[5-(6-methoxynaphthalen-1-yl)-1,3-dioxan-2-yl]propyl}carbamate
Smiles: COC1=CC2=CC=CC(C3COC(CCCNC(=O)OCC(N)=O)OC3)=C2C=C1
InChiKey: OGKKHZMANPWMSD-UHFFFAOYSA-N
InChi: InChI=1S/C21H26N2O6/c1-26-16-7-8-18-14(10-16)4-2-5-17(18)15-11-27-20(28-12-15)6-3-9-23-21(25)29-13-19(22)24/h2,4-5,7-8,10,15,20H,3,6,9,11-13H2,1H3,(H2,22,24)(H,23,25)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Fatty acid amide hydrolase (FAAH) is the primary regulator of several bioactive lipid amides including anandamide. Inhibitors of FAAH are potentially useful for the treatment of pain, anxiety, depression, and other nervous system disorders. However, FAAH inhibitors must display selectivity for this enzyme relative to the numerous other serine hydrolases present in the human proteome in order to be therapeutically acceptable. SA-72 is also a carbamate inhibitor. However, SA-72 shows exceptional selectivity for FAAH. Tested carboxylesterases are not off-targets for SA-72. SA-72 does not have major effects on the level of carboxylesterase activities in liver microsomes.
Products are for research use only. Not for human use.
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