Xenin-8

Xenin-8, a C-terminal octapeptide, is a biologically active fragment of Xenin. Xenin is a 25-amino acid peptide of the neurotensin/xenopsin family. Xenin-8 stimulates basal insulin secretion and potentiates the insulin response to glucose in a dose-dependent manner (EC50=0.16 nM).

Product information

CAS Number: 117442-28-1

Molecular Weight: 1046.27

Formula: C51H79N15O9

Chemical Name: (2S)-2-[(Z)-[(2S,3S)-2-[(Z)-[(2S)-2-[(Z)-{[(2S)-1-[(2S)-2-[(Z)-[(2S)-6-amino-2-[(Z)-{[(2S)-1-[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl](hydroxy)methylidene}amino]-1-hydroxyhexylidene]amino]-5-carbamimidamidopentanoyl]pyrrolidin-2-yl](hydroxy)methylidene}amino]-1-hydroxy-3-(1H-indol-3-yl)propylidene]amino]-1-hydroxy-3-methylpentylidene]amino]-4-methylpentanoic acid

Smiles: CC(C)C[C@H](/N=C(\O)/[C@@H](/N=C(\O)/[C@H](CC1=CNC2=CC=CC=C12)/N=C(\O)/[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)/N=C(\O)/[C@H](CCCCN)/N=C(\O)/[C@@H]1CCCN1C(=O)[C@@H](N)CC1=CN=CN1)[C@@H](C)CC)C(O)=O

InChiKey: QNDRYLNMRDPBTI-OBOKMFOZSA-N

InChi: InChI=1S/C51H79N15O9/c1-5-30(4)42(47(71)63-39(50(74)75)23-29(2)3)64-44(68)38(24-31-26-58-35-14-7-6-13-33(31)35)62-46(70)41-18-12-22-66(41)49(73)37(16-10-20-57-51(54)55)61-43(67)36(15-8-9-19-52)60-45(69)40-17-11-21-65(40)48(72)34(53)25-32-27-56-28-59-32/h6-7,13-14,26-30,34,36-42,58H,5,8-12,15-25,52-53H2,1-4H3,(H,56,59)(H,60,69)(H,61,67)(H,62,70)(H,63,71)(H,64,68)(H,74,75)(H4,54,55,57)/t30-,34-,36-,37-,38-,39-,40-,41-,42-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Xenin-8 augments Arginine-induced insulin release (by 40%) and potentiates the glucagon responses to both Arginine (by 60%), Carbachol (by 50%). Xenin-8 counteracts the inhibition of glucagon release induced by increasing the glucose concentration.

Products are for research use only. Not for human use.