Description
Climbazole (BAY-e 6975) is a potent antifungal agent. Climbazole also is a potent inducer of rat hepatic cytochrome P450.
Product information
CAS Number: 38083-17-9
Molecular Weight: 292.76
Formula: C15H17ClN2O2
Chemical Name: 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one
Smiles: CC(C)(C)C(=O)C(OC1C=CC(Cl)=CC=1)N1C=NC=C1
InChiKey: OWEGWHBOCFMBLP-UHFFFAOYSA-N
InChi: InChI=1S/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : ≥ 47 mg/mL (160.54 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Climbazole (20 µM; 48 hours) significantly decreases exosome secretion in aggressive prostate cancer (PCa) cells. Climbazole (20 µM) significantly inhibits the protein concentration of Alix, and Rab27a but not nSMase2. Climbazole is a potent inhibitor of exosome biogenesis and/or secretion.
Products are for research use only. Not for human use.
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