Climbazole


Catalog No. Size PriceQuantity
M19514-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Climbazole (BAY-e 6975) is a potent antifungal agent. Climbazole also is a potent inducer of rat hepatic cytochrome P450.

Product information

CAS Number: 38083-17-9

Molecular Weight: 292.76

Formula: C15H17ClN2O2

Chemical Name: 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one

Smiles: CC(C)(C)C(=O)C(OC1C=CC(Cl)=CC=1)N1C=NC=C1

InChiKey: OWEGWHBOCFMBLP-UHFFFAOYSA-N

InChi: InChI=1S/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 47 mg/mL (160.54 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Climbazole (20 µM; 48 hours) significantly decreases exosome secretion in aggressive prostate cancer (PCa) cells. Climbazole (20 µM) significantly inhibits the protein concentration of Alix, and Rab27a but not nSMase2. Climbazole is a potent inhibitor of exosome biogenesis and/or secretion.

Products are for research use only. Not for human use.

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