Description
GNE-955 is a potent and orally active pan Pim kinase inhibitor with Kis of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively.
Product information
CAS Number: 1527523-39-2
Molecular Weight: 416.48
Formula: C22H24N8O
Chemical Name: (3S)-1-{3-methoxy-6-[6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl]pyridin-2-yl}piperidin-3-amine
Smiles: CC1=CN=CC(=N1)C1=CC2=C(C=NN2C2=CC=C(OC)C(=N2)N2C[C@@H](N)CCC2)C=N1
InChiKey: FPBWUTAWSOLPQI-INIZCTEOSA-N
InChi: InChI=1S/C22H24N8O/c1-14-9-24-12-18(27-14)17-8-19-15(10-25-17)11-26-30(19)21-6-5-20(31-2)22(28-21)29-7-3-4-16(23)13-29/h5-6,8-12,16H,3-4,7,13,23H2,1-2H3/t16-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
GNE-955 inhibits proliferation of MM.1S cells, with an IC50 value of 0.5 μM after 72 hours treatment. GNE-955 (0.156-5 μM) inhibits the phosphorylation of BAD (s112), S6 (s235/236), S6 (s240/244) and 4EBP (s65), shows no effect on total BAD, S6 or 4EBP protein levels.
Products are for research use only. Not for human use.
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