Biphenylindanone A


Catalog No. Size PriceQuantity
M19544-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Biphenylindanone A (BINA) is a selective human mGluR2 (hmGluR2) potentiator for the treatment of many neurological disorders.

Product information

CAS Number: 866823-73-6

Molecular Weight: 454.56

Formula: C30H30O4

Chemical Name: 3'-({[(2S)-2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}methyl)-[1,1'-biphenyl]-4-carboxylic acid

Smiles: CC1=C(C=C2C[C@@H](C3CCCC3)C(=O)C2=C1C)OCC1C=C(C=CC=1)C1C=CC(=CC=1)C(O)=O

InChiKey: KMKBEESNZAPKMP-SANMLTNESA-N

InChi: InChI=1S/C30H30O4/c1-18-19(2)28-25(15-26(29(28)31)22-7-3-4-8-22)16-27(18)34-17-20-6-5-9-24(14-20)21-10-12-23(13-11-21)30(32)33/h5-6,9-14,16,22,26H,3-4,7-8,15,17H2,1-2H3,(H,32,33)/t26-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Biphenylindanone A (BINA) shows activity on glutamate-induced scintillation proximity assay [3H]IP1 hydrolysis on WT mGluR2 (EC50=1.57 μM) in the absence or presence of 5 μM glutamate.

Products are for research use only. Not for human use.

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