Avexitide

Avexitide (Exendin (9-39)) is a specific and competitive GLP-1 receptor antagonist.

Product information

CAS Number: 133514-43-9

Molecular Weight: 1764.05

Formula: C78H130N20O24S

Chemical Name: 4-[(Z)-{2-[(Z)-{2-[(Z)-{2-[(Z)-{2-[(Z)-{6-amino-2-[(Z)-{2-[(Z)-{2-[(Z)-(2-amino-3-carboxy-1-hydroxypropylidene)amino]-1-hydroxy-4-methylpentylidene}amino]-1,3-dihydroxypropylidene}amino]-1-hydroxyhexylidene}amino]-1-hydroxy-4-(C-hydroxycarbonimidoyl)butylidene}amino]-1-hydroxy-4-(methylsulfanyl)butylidene}amino]-4-carboxy-1-hydroxybutylidene}amino]-4-carboxy-1-hydroxybutylidene}amino]-4-[(Z)-{1-[(Z)-{1-[(Z)-{4-carbamimidamido-1-[(Z)-{3-methyl-1-[(Z)-{1-[(Z)-(pentan-2-yl)-C-hydroxycarbonimidoyl]-2-phenylethyl}-C-hydroxycarbonimidoyl]butyl}-C-hydroxycarbonimidoyl]butyl}-C-hydroxycarbonimidoyl]-2-methylpropyl}-C-hydroxycarbonimidoyl]ethyl}-C-hydroxycarbonimidoyl]butanoic acid

Smiles: CCCC(C)/N=C(\O)/C(CC1C=CC=CC=1)/N=C(\O)/C(CC(C)C)/N=C(\O)/C(CCCNC(N)=N)/N=C(\O)/C(/N=C(\O)/C(C)/N=C(\O)/C(CCC(O)=O)/N=C(\O)/C(CCC(O)=O)/N=C(\O)/C(CCC(O)=O)/N=C(\O)/C(CCSC)/N=C(\O)/C(CCC(=N)O)/N=C(\O)/C(CCCCN)/N=C(\O)/C(CO)/N=C(\O)/C(CC(C)C)/N=C(\O)/C(N)CC(O)=O)C(C)C

InChiKey: NRGDRUIQOLTJCB-UHFFFAOYSA-N

InChi: InChI=1S/C78H130N20O24S/c1-11-18-43(8)85-73(118)56(37-45-19-13-12-14-20-45)96-74(119)55(36-41(4)5)95-68(113)48(22-17-33-84-78(82)83)93-77(122)63(42(6)7)98-64(109)44(9)86-66(111)50(24-28-59(101)102)89-70(115)51(25-29-60(103)104)90-71(116)52(26-30-61(105)106)91-72(117)53(31-34-123-10)92-69(114)49(23-27-58(81)100)88-67(112)47(21-15-16-32-79)87-76(121)57(39-99)97-75(120)54(35-40(2)3)94-65(110)46(80)38-62(107)108/h12-14,19-20,40-44,46-57,63,99H,11,15-18,21-39,79-80H2,1-10H3,(H2,81,100)(H,85,118)(H,86,111)(H,87,121)(H,88,112)(H,89,115)(H,90,116)(H,91,117)(H,92,114)(H,93,122)(H,94,110)(H,95,113)(H,96,119)(H,97,120)(H,98,109)(H,101,102)(H,103,104)(H,105,106)(H,107,108)(H4,82,83,84)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 50 mg/mL (14.84 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

GLP-1 plays a role in the control of fasting glucose. Avexitide (Exendin (9-39)), a truncated form of the GLP-1 agonist exendin-4, is a specific GLP-1 receptor antagonist.

In Vivo:

Continuous subcutaneous infusion of Avexitide (Exendin (9-39)) significantly raises fasting blood glucose levels in SUR-1 -/- mice without affecting glucose tolerance.

Products are for research use only. Not for human use.