Description
Danirixin is a selective, and reversible CXCR2 antagonist, with IC50 of 12.5 nM for CXCL8.
Product information
CAS Number: 954126-98-8
Molecular Weight: 441.90
Formula: C19H21ClFN3O4S
Chemical Name: 1-{4-chloro-2-hydroxy-3-[(3S)-piperidine-3-sulfonyl]phenyl}-3-(3-fluoro-2-methylphenyl)urea
Smiles: CC1C(F)=CC=CC=1NC(=O)NC1=CC=C(Cl)C(=C1O)S(=O)(=O)[C@@H]1CNCCC1
InChiKey: NGYNBSHYFOFVLS-LBPRGKRZSA-N
InChi: InChI=1S/C19H21ClFN3O4S/c1-11-14(21)5-2-6-15(11)23-19(26)24-16-8-7-13(20)18(17(16)25)29(27,28)12-4-3-9-22-10-12/h2,5-8,12,22,25H,3-4,9-10H2,1H3,(H2,23,24,26)/t12-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 8 mg/mL (18.10 mM; Need ultrasonic and warming).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Danirixin is a small molecule, CXCR2 antagonist being evaluated as a potential anti-inflammatory medicine.
Products are for research use only. Not for human use.
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