Description
PU-WS13 is a selective Grp94 inhibitor, with an EC50 of 0.22 μM.
Product information
CAS Number: 1454619-14-7
Molecular Weight: 411.35
Formula: C17H20Cl2N6S
Chemical Name: 8-[(3,5-dichlorophenyl)sulfanyl]-9-{3-[(propan-2-yl)amino]propyl}-9H-purin-6-amine
Smiles: CC(C)NCCCN1C2=NC=NC(N)=C2N=C1SC1C=C(Cl)C=C(Cl)C=1
InChiKey: JYSLFQTWNRYWJT-UHFFFAOYSA-N
InChi: InChI=1S/C17H20Cl2N6S/c1-10(2)21-4-3-5-25-16-14(15(20)22-9-23-16)24-17(25)26-13-7-11(18)6-12(19)8-13/h6-10,21H,3-5H2,1-2H3,(H2,20,22,23)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : ≥ 40 mg/mL (97.24 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PU-WS13 is a Grp94 inhibitor, with an EC50 of 0.22 μM. PU-WS13 also slightly suppresses Hsp90α, Hsp90β and Trap-1, with EC50s of 27.3, 41.8 and 7.3 μM, respectively. PU-WS13 (2.5-20 μM) shows no toxicity on two nonmalignant cell lines. PU-WS13 (15 μM) disrupts the circular architecture of HER2 at the plasma membrane of SKBr3 cells mediated through Grp94. PU-WS13 inhibits Grp94, and the inhibition induces apoptosis in and reduce the viability of HER2 overexpressing breast cancer cells.
Products are for research use only. Not for human use.
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