ARQ 621


Catalog No. Size PriceQuantity
M19604-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

ARQ 621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule-based ATPase motor protein involved in cell division. Anti-tumor activity. ARQ 621 is a kinesin inhibitor.

Product information

CAS Number: 1095253-39-6

Molecular Weight: 552.43

Formula: C28H24Cl2FN5O2

Chemical Name: N-(3-aminopropyl)-3-chloro-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylamino)-3,4-dihydroquinazolin-2-yl]but-3-yn-1-yl]-2-fluorobenzamide

Smiles: C#CC[C@H](C1=NC2C=C(Cl)C=CC=2C(=O)N1NC1C=CC=CC=1)N(CCCN)C(=O)C1C=CC=C(Cl)C=1F

InChiKey: UPJSUQWHUVLLNW-XMMPIXPASA-N

InChi: InChI=1S/C28H24Cl2FN5O2/c1-2-8-24(35(16-7-15-32)27(37)21-11-6-12-22(30)25(21)31)26-33-23-17-18(29)13-14-20(23)28(38)36(26)34-19-9-4-3-5-10-19/h1,3-6,9-14,17,24,34H,7-8,15-16,32H2/t24-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Over-expression of Eg5 causes genomic instability and tumor formation in mice; therefore, Eg5 is a potential anti-cancer target.

Products are for research use only. Not for human use.

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