Description
Splitomicin (Splitomycin) is a selective Sir2p inhibitor. Splitomicin inhibits NAD+-dependent HDAC activity of Sir2 protein. Splitomicin induces dose-dependent inhibition of HDAC in the yeast extract with an IC50 of 60 μM.
Product information
CAS Number: 5690-03-9
Molecular Weight: 198.22
Formula: C13H10O2
Chemical Name: 1H,2H,3H-naphtho[2,1-b]pyran-3-one
Smiles: O=C1CCC2C(=CC=C3C=CC=CC=23)O1
InChiKey: ISFPDBUKMJDAJH-UHFFFAOYSA-N
InChi: InChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (504.49 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Splitomicin(10-333 μM;处理 24 小时)对 MCF-7 和 H1299 细胞具有抗增殖作用,这种作用存在浓度依赖性。Splitomicin 在 33 μM 浓度时不能减少菌落数,但在 100 和 333 μM 时有效抑制 MCF-7 和 H1299 细胞的菌落形成。
In Vivo:
Splitomicin (作用于 C57BL/6 小鼠,给药剂量为 80 mg/kg,每 24 小时腹腔注射一次,给药 5 天) 增强动脉血管壁中的组织因子 (TF)活性并加速颈动脉血栓形成。
Products are for research use only. Not for human use.
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