Splitomicin


Catalog No. Size PriceQuantity
M19839-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Splitomicin (Splitomycin) is a selective Sir2p inhibitor. Splitomicin inhibits NAD+-dependent HDAC activity of Sir2 protein. Splitomicin induces dose-dependent inhibition of HDAC in the yeast extract with an IC50 of 60 μM.

Product information

CAS Number: 5690-03-9

Molecular Weight: 198.22

Formula: C13H10O2

Chemical Name: 1H,2H,3H-naphtho[2,1-b]pyran-3-one

Smiles: O=C1CCC2C(=CC=C3C=CC=CC=23)O1

InChiKey: ISFPDBUKMJDAJH-UHFFFAOYSA-N

InChi: InChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (504.49 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Splitomicin(10-333 μM;处理 24 小时)对 MCF-7 和 H1299 细胞具有抗增殖作用,这种作用存在浓度依赖性。Splitomicin 在 33 μM 浓度时不能减少菌落数,但在 100 和 333 μM 时有效抑制 MCF-7 和 H1299 细胞的菌落形成。

In Vivo:

Splitomicin (作用于 C57BL/6 小鼠,给药剂量为 80 mg/kg,每 24 小时腹腔注射一次,给药 5 天) 增强动脉血管壁中的组织因子 (TF)活性并加速颈动脉血栓形成。

Products are for research use only. Not for human use.

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