Description
Dihydrexidine hydrochloride (DAR-0100 hydrochloride) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist, with an IC50 of 10 nM for D1 receptor. Dihydrexidine hydrochloride exhibits potent antiparkinsonian activity. Dihydrexidine hydrochloride can stimulate YAP phosphorylation.
Product information
CAS Number: 137417-08-4
Molecular Weight: 303.78
Formula: C17H18ClNO2
Chemical Name: (6aS, 12bR)-5H, 6H, 6aH, 7H, 8H, 12bH-benzo[a]phenanthridine-10, 11-diol hydrochloride
Smiles: Cl.OC1=CC2CC[C@@H]3NCC4=CC=CC=C4[C@H]3C=2C=C1O |&1:7,16|
InChiKey: IJYUPBNUPIRQEP-RVXRQPKJSA-N
InChi: InChI=1S/C17H17NO2.ClH/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14;/h1-4,7-8,14,17-20H,5-6,9H2;1H/t14-,17-;/m0./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 83.33 mg/mL (274.31 mM; Need ultrasonic). H2O : 10 mg/mL (32.92 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Dihydrexidine (DAR-0100) strongly increased YAP phosphorylation in U2OS cells.
In Vivo:
Dihydrexidine hydrochloride has poor oral bioavailability and a relatively short half-life of 1 to 2 h. Dihydrexidine hydrochloride (3 mg/kg; i.p.) produces prominent dopamine D1 receptor agonist effects in vivo.
Products are for research use only. Not for human use.
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