Description
B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM.
Product information
CAS Number: 1607803-67-7
Molecular Weight: 303.31
Formula: C16H17NO5
Chemical Name: 7-(1,3-dioxan-2-yl)-8-hydroxy-1H,2H,3H,4H,5H-chromeno[3,4-c]pyridin-5-one
Smiles: OC1=CC=C2C(OC(=O)C3CNCCC=32)=C1C1OCCCO1
InChiKey: UYYMWNUDIOPESF-UHFFFAOYSA-N
InChi: InChI=1S/C16H17NO5/c18-12-3-2-10-9-4-5-17-8-11(9)15(19)22-14(10)13(12)16-20-6-1-7-21-16/h2-3,16-18H,1,4-8H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 8.33 mg/mL (27.46 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM. Treatment of CLL cells with this inhibitor (B I09) mimick XBP-1 deficiency, including upregulation of IRE-1 expression and compromised BCR signaling. B I09 is highly effective in inhibiting splicing of XBP1 mRNA in human WaC3 cells and the expression of XBP-1s in LPS stimulated B cells.
In Vivo:
B I09 has a halflife of approximately 1.5 hours and reaches its peak concentration of approximately 39 μM in mouse plasma serum 15 minutes after administration. Administration of B I09 to CLL tumor-bearing mice suppress leukemic progression by inducing apoptosis and do not cause systemic toxicity.
Products are for research use only. Not for human use.
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