Description
LEP(116-130)(mouse) is a synthetic leptin peptide fragment.
Product information
CAS Number: 258276-95-8
Molecular Weight: 1560.73
Formula: C64H109N19O24S
Chemical Name: 4-{[1-(6-amino-2-{2-[2-(2-{2-[2-(2-{[1-(2-{2-[2-(2-amino-3-hydroxypropanamido)-3-sulfanylpropanamido]-3-hydroxypropanamido}-4-methylpentanoyl)pyrrolidin-2-yl]formamido}-4-carbamoylbutanamido)-3-hydroxybutanamido]-3-hydroxypropanamido}acetamido)-4-methylpentanamido]-4-carbamoylbutanamido}hexanoyl)pyrrolidin-2-yl]formamido}-4-[(1-carbamoyl-2-hydroxyethyl)carbamoyl]butanoic acid
Smiles: CC(O)C(NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(CS)NC(=O)C(N)CO)C(=O)NC(CO)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCC(N)=O)C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CCC(O)=O)C(=O)NC(CO)C(N)=O
InChiKey: YEHDWBRMEXDYLT-UHFFFAOYSA-N
InChi: InChI=1S/C64H109N19O24S/c1-30(2)22-38(57(100)72-34(13-16-46(67)89)54(97)75-37(10-6-7-19-65)63(106)82-20-8-11-44(82)60(103)74-36(15-18-49(92)93)55(98)77-40(26-85)51(69)94)71-48(91)24-70-53(96)41(27-86)79-62(105)50(32(5)88)81-56(99)35(14-17-47(68)90)73-61(104)45-12-9-21-83(45)64(107)39(23-31(3)4)76-58(101)42(28-87)78-59(102)43(29-108)80-52(95)33(66)25-84/h30-45,50,84-88,108H,6-29,65-66H2,1-5H3,(H2,67,89)(H2,68,90)(H2,69,94)(H,70,96)(H,71,91)(H,72,100)(H,73,104)(H,74,103)(H,75,97)(H,76,101)(H,77,98)(H,78,102)(H,79,105)(H,80,95)(H,81,99)(H,92,93)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: H2O : 50 mg/mL (32.04 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
LEP-(116-130) (300 µM) is unable to inhibit AP-OB binding.
In Vivo:
LEP-(116-130) (1 mg, i.p.) results in a reduced rate of body weight gain in the presence of increased food intake compared with vehicle-injcted control mice. LEP-(116-130) significantly reduces blood glucose levels by appr 100 mg/dL. Administration of LEP-(116-130) to wild-type (+/+) C57BLKS/J-m mice for 4 or 7 days has no effect on their ability to thermoregulate.
Products are for research use only. Not for human use.
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