GW-803430


Catalog No. Size PriceQuantity
M20002-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

GW-803430 (GW-3430) is a potent and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pIC50 of 9.3. GW-803430 is orally active in an animal model of obesity.

Product information

CAS Number: 515141-51-2

Molecular Weight: 481.99

Formula: C25H24ClN3O3S

Chemical Name: 6-(4-chlorophenyl)-3-{3-methoxy-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-3H,4H-thieno[3,2-d]pyrimidin-4-one

Smiles: COC1=CC(=CC=C1OCCN1CCCC1)N1C=NC2C=C(SC=2C1=O)C1C=CC(Cl)=CC=1

InChiKey: MWULMTACIBZPGN-UHFFFAOYSA-N

InChi: InChI=1S/C25H24ClN3O3S/c1-31-22-14-19(8-9-21(22)32-13-12-28-10-2-3-11-28)29-16-27-20-15-23(33-24(20)25(29)30)17-4-6-18(26)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

GW-803430 demonstrates a potent antagonist activity towards MCH induced MCHR1 receptor with an IC50 value of ~13 nM.

In Vivo:

GW-803430 (0.3, 3, and 15 mg/kg; oral administration; once daily) causes a sustained dose-dependent weight loss relative to vehicle controls. GW-803430 is a suitable compound for its good pharmacokinetic properties (bioavailability=31%, t1/2=11 h) and brain penetration (6:1 brain:plasma concentration) in mice.

Products are for research use only. Not for human use.

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